Monday, February 28, 2011

UNICEF - Nepal - Women health volunteers save children’s lives in Nepal


Women health volunteers save children’s lives in Nepal

UNICEF Image
© UNICEF video
Vitamin A supplements like those administered here by Ganga Thapa save an estimated 12,000 children’s lives annually in Niger.
By Jane O’Brien
Every year 10.5 million children die before the age of five, the vast majority from preventable causes. On 18 September, a high-level Child Survival Symposium in New York will galvanize action to reduce child deaths by two-thirds by 2015, in line with Millennium Development Goal 4. Here is the third in a series of UNICEF reports in the run-up to the symposium.
NEW YORK, USA, 15 September 2006 – Ganga Thapa has been a volunteer health worker for 16 years. She’s part of a growing network of women, supported by UNICEF, who bring essential care and medicines to children and mothers in remote Nepalese communities.
“My happiest moment is when I am able to cure pneumonia,” she says. “Before, lots of children used to die from pneumonia, but now I think nobody dies of it in this area.”
Treatment and prevention
Since it started in 1988, the Female Community Health Volunteer programme has been critical to reducing the mortality rate of children under the age of five. There are now some 48,000 women operating in all 75 districts.
As well as being able to treat potentially fatal diseases such as pneumonia and diarrhoea, the women also ensure that children are immunized against preventable diseases.
“They are participating in the campaign of distributing Vitamin A, polio eradication and de-worming,” says Tanahu District Health Officer Dr. Kedar Prasad Century. “It is not only good for our village but also good for our country.”
Infant mortality rate halved
Vitamin A supplements can reduce under-five mortality rates by 30 percent, and the programme in Nepal saves an estimated 12,000 children’s lives every year. It prevents a further 2,000 from going blind. Thanks to the women volunteers, 3.3 million children in all of the country’s 75 districts receive the supplements.
“The women are really inspired and care about their work,” says Dr. Century. “They are becoming popular and have good relations with the villagers. They also participate in mothers' groups and refer a lot of people to us. They have good positions in the village and in some places they are working full-time.”
The infant mortality rate has almost halved in the last 15 years as initiatives like the Female Health Care Volunteer programme continue to make a difference to some of Nepal’s most vulnerable children.

UNICEF - Nepal - Women health volunteers save children’s lives in Nepal

Sunday, February 27, 2011

MSF Slideshow - Treating Malnutrition in Bangladesh


SLIDESHOW: TREATING MALNUTRITION IN BANGLADESH'S CAPITAL

Bangladesh / 21.10.10

Photographer Julie Remy documented life and Médecins Sans Frontières' work in the Dhaka slum of Kamrangirchar, a rapidly expanding settlement on the banks of a badly polluted river where health needs are significant and often go unmet.


Slideshow


MORE FROM BANGLADESH

Bangladesh: Slum conditions pose a hazard to health

It is still early in the morning, but the narrow alleyways of Kamrangirchar are already bustling with activity. The screeching sound of wood being sawed, the clunk of metal being hammered into shape, and the cacophony of small...

Hope for Kala Azar Sufferers in Bangladesh

FULBARIA, Bangladesh, June 19, 2010 - Today, a new medical programme bringing hope to thousands of kala azar sufferers in Bangladesh is being launched by humanitarian medical aid organisation Médecins Sans Frontières in...

MORE ON MALNUTRITION

Niger between two seasons of hunger

Despite the large-scale response to the nutritional crisis from Médecins Sans Frontières and many other organisations, tens of thousands of children suffered from malnutrition in Niger in 2010. In spite of better harvests, 2011...

Civilians bearing brunt of increased violence and insecurity in eastern Democratic Republic of Congo says Médecins Sans Frontières

28  January 2011 – The international emergency medical humanitarian organisation Médecins Sans Frontières has provided specialised care to 53 women, men and children who were raped in a series of incidents that occurred between...

Source: MSF 

Saturday, February 26, 2011

MSF REPORT - Year In Focus 2010


YEAR IN FOCUS: 2010


In this interactive booklet we provide a month-by-month overview of our medical humanitarian activities throughout last year. From the devastating earthquake that struck Haiti in January through to December with the Kala Azar outbreak in southern Sudan.

Related news:

INTERACTIVE BOOKLET

Thursday, February 24, 2011

MSF: Letters From The Field

REACHING OUT TO PEOPLE TRAPPED BY CONFLICT
Democratic Republic of Congo

© JP Amigo / MSF
“I met people whose villages had been burnt to the ground by one military group or another; they had run into the bush and were living with trees over the top of them and no mosquito nets. The malaria – I’d never seen anything like it.”

Tom de Kok’s first field placement for Médecins Sans Frontières was in Pakistan after the earthquake in 2005. Since then he has worked for Médecins Sans Frontières in Darfur and in Iraq and has completed two field missions in the Democratic Republic of Congo.

Tom is an Médecins Sans Frontières project coordinator who has returned from North Kivu, in the east of the Democratic Republic of Congo, where violent conflict persists between government forces and an array of military groups. Around the town of Pinga, the frontlines between different armed actors constantly shift, and local people are trapped in the middle. Those displaced from their villages by the fighting hide in makeshift shelters in the forest, not knowing where the next danger will come from and often cut off from all medical care.

For some, even travelling to town for provisions as basic as salt is too dangerous, as they run the risk of robbery, extortion and harassment. “In one village I came across, people had no salt. We’re a medical organisation, but we can still barely imagine that people are desperate to get salt.”

Huge health needs

In such an insecure and unstable environment, where many lack the most basic necessities, people’s health needs are huge. Despite the enormous challenges of working in a conflict zone, across shifting frontlines, Médecins Sans Frontières is running a therapeutic feeding centre for malnourished children in Pinga town, supporting two health centres in the surrounding area, and running mobile clinics on motorbikes. Médecins Sans Frontières staff in Pinga carried out 40,000 consultations in 2010.

Continual conflict

“Most people – even old people – don’t know what it’s like to live without conflict; it has always been part of daily life. But still, the people who live in Pinga town have a far different experience from somebody who lives just five kilometres away, on the other side of the frontline. Whole villages are often burnt to the ground by non-government militias to deter nearby government forces from advancing and occupying them. When this happens, the villagers are forced to hide in the forest in makeshift shelters, without mosquito nets.”

Malaria is endemic

It is no surprise that in the hot, rainy, densely forested hills around Pinga, malaria is endemic. In 2010, the team in Pinga treated more than 6,500 cases. Children with malaria are particularly likely to have life-threatening complications, but getting these children to a doctor in town is far from straightforward.

Trying to cross the frontline

To get medical care or reach the hospital in Pinga town, villagers “have to cross frontlines and land controlled by different military groups. They are accused by all sides of being sympathisers. If they follow the main road they’ll run into checkpoints. And if they take a back road through the woods, they’re going to run into the military – either government or non-government forces – and then they’ll be forced to explain why they’re travelling on the back road and it will look even more suspicious. When there’s all-out fighting, the military suspects everybody. These are serious cases: these are parents with a dying infant who has got malaria maybe with anaemic complications. They’ll move, they’ll get harassed, they’ll turn around and the result is their child won’t make it.”

Mobile clinic by motorbike

With so many people prevented from going to find a doctor, Médecins Sans Frontières' mobile teams are crossing the frontlines themselves, and travelling on motorbikes into the dense bush to find the sick and traumatised people who are so desperately in need of help. “Road conditions are horrible; we do our mobile clinics with motorcycle convoys because cars can’t go there.”

Transferring patients

For many patients, on-the-spot treatment is not enough, and they need to be transferred to the nearest hospital, which may be across two frontlines and territory controlled by three different warring groups. In these cases, “the endeavour of trying to transfer a patient is about as lifesaving as the medical care itself. We cannot just transport sick patients on motorbikes for hours over rough terrain – children cannot hold on; neither can pregnant women. We fill out a referral form and try to get them to meet us at the checkpoint so we can cross together with them. We tell the armed men at checkpoints the names of those patients who will attempt to cross that day, and we tell them we will follow up on these people. But still, some never arrive at our clinics on the other side of the frontline.” Médecins Sans Frontières teams are trying to find ways around these difficulties.

Treating rape survivors

Médecins Sans Frontières also provides specialised medical care to women and girls who have been raped. Treatment includes post-exposure prophylaxis, which can help protect against the HIV virus and other sexually transmitted infections. Sexual violence is a terrible part of the war in eastern Congo that is perpetrated by military groups on all sides of the conflict. Many women are afraid to seek treatment because of fear of being stigmatised by their families. They also risk further harassment when attempting to cross military checkpoints in search of medical care. In 2010, the team provided specialised medical care to more than 200 women and girls who managed to reach Médecins Sans Frontières’ clinics against all the odds.

Maternal healthcare

Providing maternal healthcare is another major priority, as women living in the bush who suffer complications during pregnancy and childbirth have no access to doctors or trained midwives. In and around Pinga in 2010, Médecins Sans Frontières carried out 4,000 antenatal consultations and 65 babies were delivered within a Médecins Sans Frontières facility.

Médecins Sans Frontières’ added value

Despite the difficulties of travelling by motorbike on muddy jungle tracks, of being held up at checkpoints, of negotiating access across frontlines and having to deal with various armed groups, Médecins Sans Frontières is capable of working in these conditions. “Our reputation on the ground is better than good. We’ve got the maximum amount of space you could have under these difficult circumstances. We are still reaching people in need and our work is respected across the lines.”

  
LOCATION MAP - DEMOCRATIC REPUBLIC OF CONGO -

Tuesday, February 22, 2011

Roll Back Malaria Update February 2011



Malaria In The News - February 2011

Source: Roll Back Malaria 21.02.2011
Read this issue and previous issues online.
Announcements / Press Releases
Vector Control Working Group plans for 2011 at 6th annual meeting [RBM VCWG] — (English)
At its largest meeting to date, 120 members of the Roll Back Malaria Vector Control Working Group (VCWG) gathered to discuss current and emerging issues on global malaria vector control. Representing a range of regions, national programmes and organizations, participants reviewed progress made to date by the working group's eight workstreams. A work plan for 2011 was also established, to be coordinated with WHO's Global Malaria Programme and partners. View Communique and presentations of the Meeting...

Work begins on new guidance framework for behaviour change communication [RBM] — (English)
Roll Back Malaria partners working in Behavior Change Communication (BCC), vital to improve the uptake of all malaria interventions, met in Geneva to develop BCC guidelines for countries, the Global Fund and other donor agencies. Key next steps will include the development of indicators and best practices which can inform the preparation of upcoming Global Fund proposals, as well as training sessions for consultants, the Technical Review Panel and other partners...

Alliance for Malaria Prevention partners count their success stories, discuss challenges [AMP, RBM] — (English)
At a meeting organized by the Alliance for Malaria Prevention, a workstream of the Roll Back Malaria Harmonization working group, over 100 representatives from partner organizations reviewed successes and established future research priorities. Participants focused on producing a clearer definition of universal coverage and on ways to increase the coverage and use of long-lasting insecticide-treated nets (LLINs). Discussion also covered successes in behaviour change communication, monitoring and evaluation and scaling up LLIN coverage, with participants reviewing in-depth examples from six African countries...

Jomaa Pharma and MMV to co-develop novel malaria treatment based on fosmidomycin [MMV] — (English)
Jomaa Pharma GmbH, a German biopharmaceutical company engaged in malaria chemotherapy, and Medicines for Malaria Venture (MMV) a not-for-profit research foundation, announced today that they have signed a Memorandum of Understanding for the joint development of fosmidomycin, as a component of non-artemisinin based combination therapy (NACT), for acute Plasmodium falciparum malaria. Fosmidomycin is a molecule that possesses antimalarial and antibacterial activity. The stimulus for this co-development project follows reports of the emergence of artemisinin resistance on the Thai-Cambodian border...

Dr Jan Van Erps, conseiller principal de Roll Back Malaria sur la suppression des taxes de douane sur les médicaments antipaludéens
[RFI, 22:24] — (French)
Les défenseurs de la lutte contre le paludisme appellent à la suppression des taxes de douane sur ces médicaments d'importance vitale...

Targeting malaria's liver stage [TropIKA] — (English)
Researchers at the University of South Florida and the Massachusetts-based Charles Stark Draper Laboratory have received two Gates Foundation grants totalling $5.45 million to develop advanced devices capable of creating tissue models that mimic the human liver. The devices could accelerate drug discovery and vaccine development for malaria by allowing researchers to better understand the parasite's liver stage, where it may be most vulnerable to attack...

Malaria parasites [Wellcome Trust] — (English)
New research from the University of Edinburgh shows that malarial parasites gather information from their environment to strike a delicate balance between the two...

Job oppotunities at CRS, MMV, PATH [RBM] — (English)
Job descriptions and links to online application forms...
21.02.2011

Tulane University joins quest to wipe out malaria [Times-Picayune] — (English)
he vaccine, which will be administered where malaria is rife, will target the disease-causing parasites mosquitoes carry, said Nirbhay Kumar, chairman of Tulane's Department of Tropical Medicine......
20.02.2011

Floating spores kill malaria mosquito larvae [Science Daily] — (English)
New research published in BioMed Central's open access journal Parasites and Vectors presents a method of dispersing pathogenic fungi as a means of preventing the spread of malaria......
19.02.2011

Sweet Bait Lures Malaria Mosquitoes [Voice of America] — (English)
Israeli researchers say they have developed a powerful bait that effectively attracts and kills malaria-infected mosquitoes but is completely harmless to humans and other animals......

Why a spider that likes smelly socks could help fight against malaria [BBC] — (English)
Scientists in Kenya say they have discovered a mosquito-eating spider that is drawn to the smell of human sweat......

Alte Socken locken Spinne an [Spiegel] — (German)
Eine kenianische Spinne zieht es zu alten Socken. Das haben Forscher in Versuchen mit getragenen und sauberen Baumwollstrümpfen herausgefunden......

Dreckige Socken ziehen afrikanische Springspinnen an [Zeit] — (German)
Eine ostafrikanische Spinnenart folgt dem Gestank durchgeschwitzter Socken. Der Geruch des Menschen führt den Achtbeiner zu seiner Beute: Blutsaugende Moskitos......

SLU, Chinese scientists team up to tackle malaria [St. Louis Post-Dispatch] — (English)
Researchers at St. Louis University have teamed up with scientists at a Chinese health institute to study potential malaria treatments......

Misleading strides in malaria fight [Mail and Guardian Online] — (English)
At the dawn of the new millennium, hospitals and clinics in northern KwaZulu-Natal were inundated with patients and graveyards were filling up fast......

Malaria cases could affect MDGs attainment - Dr Abenyeri [Ghana News Agency] — (English)
Dr John Abenyeri, Northern Regional Malaria Coordinator, has warned that failure of the country to reduce the increasing cases of malaria could affect efforts at attaining the Millennium Development Goal......
18.02.2011

Reductions in malaria and anaemia case and death burden at hospitals following scale-up of malaria control in Zanzibar, 1999-2008 [Malaria Journal 2011, 10:46 ] — (English)
Scaling-up effective malaria interventions in Zanzibar reduced malaria-related burden at health facilities by over 75% within 5 years. In high-malaria settings, intensified malaria control can substantially contribute to reaching the Millennium Development Goal 4 target of reducing under-five mortality by two-thirds between 1990 and 2015......

CDRI to lead consortium to develop malaria drug [Indian Express] — (English)
The Central Drug Research Institute, which is celebrating its 60th anniversary this year, will lead the Open Source Drug Development (OSDD) for malaria in the country......

The UK to support Ghana with 36 million pound Sterling [Ghana News Agency] — (English)
Vice President John Dramani Mahama on Friday announced that the UK would support Ghana with 36 million pound sterling, through the Department for International Development (DFID) to facilitate the Millennium Development Goals (MDGs)......

True versus Apparent Malaria Infection Prevalence: The Contribution of a Bayesian Approach [PLOS One] — (English)
Malaria sero-prevalence was relatively low in all sites, with ELISA showing the highest estimates. The sensitivity of microscopy and ELISA were statistically lower in Vietnam than in the other sites. Similarly, the specificities of microscopy, ELISA and PCR were significantly lower in Vietnam than in the other sites. In Vietnam and Peru, microscopy was closer to the “true” estimate than the other 2 tests while as expected ELISA, with its lower specificity, usually overestimated the prevalence......

Malaria Parasites: Disease Action and Transmission [GIT] — (English)
Malarial parasites gather information from their environment to strike a delicate balance between when to conserve energy and survive and when to spend energy reproducing - this was now shown by new research from the University of Edinburgh......
17.02.2011

Cleaning up [The Economist] — (English)
Can the Global Fund to fight Aids, Tuberculosis and Malaria restore its reputation as the best and cleanest in the aid business? ......

High-throughput 454 resequencing for allele discovery and recombination mapping in Plasmodium falciparum [BMC Genomics 2011, 12:116doi:10.1186/1471-2164-12-116] — (English)
This study is the first to resequence progeny clones to examine fine structure of COs and NCOs in malaria parasites......

District level external quality assurance (EQA) of malaria microscopy in Pakistan: pilot implementation and feasibility [Malaria Journal 2011, 10:45 ] — (English)
This paper reports on the early implementation of a district-level external quality assurance programme for malaria microscopy in four districts in Pakistan. Improving malaria microscopy on a programmatic level, and demonstrating the impact of such efforts, is a notable challenge and is of considerable interest to the many stakeholders in public health and malaria control......

New Malaria drug to be launched soon [Ghana News Agency] — (English)
A new drug known as Affordable Medicines Facility for Malaria (AMFm) which cost GH¢1.50p would soon be launched in the country, Mr. James Frimpong, an official of the National Malaria Control Prgramme (NMCP) has said......

Iron tablets, vitamin C affect efficacy of malaria drugs [Nigerian Tribune] — (English)
Medical doctors now prescribe the highly effective Artemisinin-based Combination Therapies (ACT) for the treatment of malaria. However, experts warn that taking ACT in combination with multivitamins that contain Iron and vitamin C and E renders the drug ineffective, reports Sade Oguntola......

Malaria outbreak forces Haiti to withdraw [Jamaica Gleaner] — (English)
Haiti's participation in the 12-nation CONCACAF under-17 Championship, now on in western Jamaica, was cut short yesterday when the team announced its withdrawal from the tournament after it was confirmed that malaria was the 'mystery illness' that had afflicted three players......
16.02.2011

No birth defect risk seen with malaria drug [REuters via MSNBC] — (English)
Pregnant women who take the anti-malarial drug Malarone during their first trimester might not be increasing their baby's risk of birth defects, a new study suggests......

Clooney speaks out about malaria [IoL] — (English)
George Clooney is used to creating a buzz no matter where he goes. However, on a recent trip to Sudan he experienced a buzz he could have done without......

Monitoring of clinical efficacy and in vitro sensitivity of Plasmodium vivax to chloroquine in area along Thai Myanmar border during 2009-2010 [Malaria Journal 2011, 10:44 ] — (English)
While in vivo results suggest that the standard regimen of chloroquine was still very effective for the treatment of vivax malaria in the Thai-Myanmar border area, there is some evidence of a reduced in vitro sensitivity, raise the possibility of resistance in the future......

Our global duty to fight malaria [Ohio.com] — (English)
For time beyond remembering, the people of Senegal have lost a battle with malaria, surrendering a portion of their children to fever, organ failure and death, until this terrible sacrifice seemed ordinary. The malaria-spreading mosquito is craftier than any beast of the field. After harvesting infected blood, it injects the malaria parasite in its next target. The developing parasites destroy red blood cells and overwhelm weak immune systems, particularly those of children......

Research and Markets: Malaria - Pipeline Review, Q4 2010 [Business Wire] — (English)
Research and Markets has announced the addition of Global Markets Direct's new report "Malaria - Pipeline Review, Q4 2010" to their offering......

Turning point: Collins Ouma [Nature News] — (English)
Molecular biologist Collins Ouma's efforts to combat paediatric malaria in Kenya are gaining momentum......
15.02.2011

Malaria-Fighting MSU Prof Subject of Documentary [ABC News] — (English)
Documentary on Michigan State's longtime malaria-fighting Dr. Taylor debuts on campus Tuesday......

Analysis of Two Novel Midgut-Specific Promoters Driving Transgene Expression in Anopheles stephensi Mosquitoes [PLOS One] — (English)
Our studies on two putative blood-meal induced, midgut-specific promoters validate the use of G12 upstream regulatory regions to drive targeted transgene expression coinciding spatially and temporally with pre-sporogonic stages of Plasmodium parasites in the mosquito, offering the possibility of manipulating vector competence or performing functional studies on vector-parasite interactions......

The first Finnish malariologist, Johan Haartman, and the discussion about malaria in 18th century Turku, Finland [Malaria Journal 2011, 10:43 ] — (English)
The paper deals with Dr. Haartman, a professor in medicine, appointed in Turku, at that time belonging to Finland and now neighbouring the newly Russian part of Karelia. Turku at that time, like Karelia, are known for a relatively high incidence of malaria (mostly Plasmodium vivax and, more rarely, Plasmodium malariae), a situation that persisted into the 1950s, also shared by some northern parts of Russia (Murmansk)......

Sequence and gene expression of chloroquine resistance transporter (pfcrt) in the association of in vitro drugs resistance of Plasmodium falciparum [Malaria Journal 2011, 10:42 ] — (English)
This article summarizes some interesting new findings on pfcrt sequence variants in 95 Plasmodium falciparum isolates from Thailand. These sequences were compared with drug susceptibility phenotypes. The authors report two novel PfCRT mutations – K76A and E198K, in a background of the SE Asian haplotype......

Evaluating the effectiveness of IPTi on malaria using routine health information from sentinel health centres in southern Tanzania [Malaria Journal 2011, 10:41] — (English)
The paper describes the IPTi morbidity monitoring study, in which routine health management and information services data was analysed to investigate the effect of IPTi with SP on malaria, anaemia, and all-cause attendance in children aged 2-11 months in 11 health centres in southern Tanzania......

Immunization with different PfAMA1 alleles in sequence induces clonal imprint humoral responses that are similar to responses induced by the same alleles as a vaccine cocktail in rabbits [Malaria Journal 2011, 10:40] — (English)
These findings may have implications for the current understanding of the natural acquisition of clinical immunity to malaria as well as for rational vaccine design......

Malaria rapid diagnostic kits: quality of packaging, design and labelling of boxes and components and readability and accuracy of information inserts [Malaria Journal 2011, 10:39] — (English)
Overall, malaria RDTs showed shortcomings in quality of construction, design and labelling of boxes, device packages, devices and buffers. Information inserts were difficult to read and lacked relevant information......
Articles requiring subscription
Nations with endemic malaria are urged to scrap taxes and tariffs on drugs and tests [BMJ 2011; 342:d1034] — (English)
Antimalaria advocacy groups have renewed calls for an end to taxes and tariffs on vital products used to fight the disease, including drugs, insecticide treated bed nets, and rapid diagnostic tests. Awa Marie Coll-Seck, executive director of the Roll Back Malaria Partnership, welcomed all initiatives to make these products affordable and accessible. Eliminating the tariffs—which in some countries add 40% to 50% to the price of antimalarial products, would help slash costs and make them affordable and accessible to poor people, experts say...

Azithromycin for treating uncomplicated malaria [Cochrane Database of Systematic Reviews 2011, Issue 2. Art. No.: CD006688. DOI: 10.1002/14651858.CD006688.pub2] — (English)
Currently, there is no evidence for the superiority or equivalence of azithromycin monotherapy or combination therapy for the treatment of P. falciparum or P. vivax compared with other antimalarials or with the current first-line antimalarial combinations. The available evidence suggests that azithromycin is a weak antimalarial with some appealing safety characteristics. Unless the ongoing dose, formulation and product optimisation process results in a universally efficacious product, or a specific niche application is identified that is complementary to the current scala of more efficacious antimalarial combinations, azithromycin's future for the treatment of malaria does not look promising...

Use of an HRP2-based rapid diagnostic test to guide treatment of children admitted to hospital in a malaria-endemic area of north-east Tanzania [Tropical Medicine & International Health, DOI: 10.1111/j.1365-3156.2011.02737.x] — (English)
The study compares the performance of the Paracheck™ rapid diagnostic test (RDT) with microscopy for diagnosing malaria in hospitalised children. ...

Plasmodium vivax Vaccine Research: Insights from Colombian Studies [Am. J. Trop. Med. Hyg., 84(2_Suppl), 2011, pp. 1-3 doi:10.4269/ajtmh.2011.09-0781] — (English)
In recent years, heightened awareness of the heavy public health, economic, and social burdens attributable to malaria, has led to increased interest and support by both public and private sectors for malaria-related research and control...

Consistent Safety and Infectivity in Sporozoite Challenge Model of Plasmodium vivax in Malaria-Naive Human Volunteers [Am. J. Trop. Med. Hyg., 84(2_Suppl), 2011, pp. 4-11 doi:10.4269/ajtmh.2011.09-0498] — (English)
The bite of as low as two P. vivax-infected mosquitoes provides safe and reliable infections in malaria-naive volunteers, suitable for assessing antimalarial and vaccine efficacy trials...

Phase I Safety and Immunogenicity Trial of Plasmodium vivax CS Derived Long Synthetic Peptides Adjuvanted with Montanide ISA 720 or Montanide ISA 51 [Am. J. Trop. Med. Hyg., 84(2_Suppl), 2011, pp. 12-20 doi:10.4269/ajtmh.2011.09-0516] — (English)
We assessed the safety, tolerability, and immunogenicity of a mixture of three synthetic peptides derived from the Plasmodium vivax circumsporozoite protein formulated in Montanide ISA 720 or Montanide ISA 51...

Preclinical Vaccine Study of Plasmodium vivax Circumsporozoite Protein Derived-Synthetic Polypeptides Formulated in Montanide ISA 720 and Montanide ISA 51 Adjuvants [Am. J. Trop. Med. Hyg., 84(2_Suppl), 2011, pp. 21-27 doi:10.4269/ajtmh.2011.10-0110] — (English)
Here, combinations of three synthetic polypeptides corresponding to amino (N), central repeat (R), and carboxyl (C) regions of the CS protein formulated in Montanide ISA 720 or Montanide ISA 51 adjuvants were assessed for immunogenicity in rodents and primates. BALB/c mice and Aotus monkeys were divided into test and control groups and were immunized three times with doses of 50 and 100 µg of vaccine or placebo...

Plasmodium vivax Sporozoite Production in Anopheles albimanus Mosquitoes for Vaccine Clinical Trials [Am. J. Trop. Med. Hyg., 84(2_Suppl), 2011, pp. 28-34 doi:10.4269/ajtmh.2011.09-0499] — (English)
Vaccine development for Plasmodium vivax malaria is underway. A model to assess the protective efficacy of vaccine candidates in humans is urgently needed. Given the lack of continuous P. vivax cultures, we developed a system to infect Anopheles albimanus mosquitoes using blood from P. vivax-infected patients and determined parameters for challenge of malaria-naive volunteers by mosquito bite...

Antibody-Mediated and Cellular Immune Responses Induced in Naive Volunteers by Vaccination with Long Synthetic Peptides Derived from the Plasmodium vivax Circumsporozoite Protein [Am. J. Trop. Med. Hyg., 84(2_Suppl), 2011, pp. 35-42 doi:10.4269/ajtmh.2011.09-0507] — (English)
We describe the characterization of specific immune responses induced in 21 malaria-naive volunteers vaccinated with long synthetic peptides derived from the CS protein formulated in Montanide ISA 720...

Immune Responses and Protection of Aotus Monkeys Immunized with Irradiated Plasmodium vivax Sporozoites [Am. J. Trop. Med. Hyg., 84(2_Suppl), 2011, pp. 43-50 doi:10.4269/ajtmh.2011.09-0759] — (English)
These findings suggest that the Aotus monkey model may be able to play a role in preclinical development of P. vivax pre-erythrocytic stage vaccines...

Antigenic Diversity of the Plasmodium vivax Circumsporozoite Protein in Parasite Isolates of Western Colombia [Am. J. Trop. Med. Hyg., 84(2_Suppl), 2011, pp. 51-57 doi:10.4269/ajtmh.2011.09-0785] — (English)
This study confirms the high polymorphism of the repeat domain and the highly conserved nature of the flanking regions...

Evaluation of the Naturally Acquired Antibody Immune Response to the Pv200L N-terminal Fragment of Plasmodium vivax Merozoite Surface Protein-1 in Four Areas of the Amazon Region of Brazil [Am. J. Trop. Med. Hyg., 84(2_Suppl), 2011, pp. 58-63 doi:10.4269/ajtmh.2011.10-0044] — (English)
Results of this study provide evidence that Pv200L is a naturally immunogenic fragment of the PvMSP-1 and is associated with the degree of exposure to parasites. The fine specificity of antibodies to Pv200L is currently being assessed...

Polymorphism of the Pv200L Fragment of Merozoite Surface Protein-1 of Plasmodium vivax in Clinical Isolates from the Pacific Coast of Colombia [Am. J. Trop. Med. Hyg., 84(2_Suppl), 2011, pp. 64-70 doi:10.4269/ajtmh.2011.09-0517] — (English)
We found two new alleles and several previously unidentified dimorphic substitutions and significant size polymorphism. The presence of highly conserved blocks in this fragment has important implications for the development of Pv200L as a subunit vaccine candidate...

Characterization of Plasmodium vivax Transmission-Blocking Activity in Low to Moderate Malaria Transmission Settings of the Colombian Pacific Coast [Am. J. Trop. Med. Hyg., 84(2_Suppl), 2011, pp. 71-77 doi:10.4269/ajtmh.2011.10-0085] — (English)
Studies here provide preliminary data on factors of great importance for further work on the development of TB vaccines...

Resistance to Malaria Drugs [JAMA] — (English)
Warning that action is needed to prevent malarial parasites from developing resistance to artemisinin-based drugs that are critical to battling the disease, the World Health Organization (WHO) Global Malaria Programme and the Roll Back Malaria partnership last month released a plan to tackle this problem...

Herbal Medicines and Infectious Diseases: Characterization by LC-SPE-NMR of Some Medicinal Plant Extracts Used against Malaria [Planta Med : DOI: 10.1055/s-0030-1270719] — (English)
The extracts of two medicinal plants used in traditional medicine against malaria were characterized by means of an LC-SPE-NMR and LC-MS platform...

Patent Literature on Mosquito Repellent Inventions which Contain Plant Essential Oils - A Review [Planta Med : DOI: 10.1055/s-0030-1270723] — (English)
Scientific literature sources provide evidence for the mosquito repellency of many of the EOs and individual chemical components found in EOs used in patented repellent inventions...

Toxoplasma gondii sequesters centromeres to a specific nuclear region throughout the cell cycle [PNAS +] — (English)
We demonstrate that centromere attachment to the centrocone persists throughout the parasite cell cycle and that centromeres localize to a single apical region within the nucleus. Centromere sequestration provides a mechanism for the organization of the Toxoplasma nucleus and the maintenance of genome integrity...

The pharmacokinetic evaluation of artemisinin drugs for the treatment of malaria in paediatric populations [Informa, doi:10.1517/17425255.2011.557064] — (English)
The construction of a systems-based model of this subject should be a priority area in order to identify gaps in current knowledge to ensure their continued effective and safe use...

Gene profiling analysis reveals the contribution of CD24 and P2Y6R to the susceptibility of young rats to Plasmodium berghei infection [Cellular Microbiology, DOI: 10.1111/j.1462-5822.2011.01574.x] — (English)
This study contributes to the discovery of novel biomarkers in young susceptible rats and suggests that the decrease in their expression could be among the reasons for the development of severe pathology in malaria...

Olfaction-based anthropophily in a mosquito-specialist predator [Biol. Lett. doi: 10.1098/rsbl.2010.1233] — (English)
Evarcha culicivora is an unusual salticid spider because it feeds indirectly on vertebrate blood by choosing blood-carrying mosquitoes as preferred prey. Its preferred mosquitoes are Anopheles, the genus to which all human malaria vectors belong. Here, we show that human odour, which is known to be salient to malaria vectors, is also salient to the adults and juveniles of E. culicivora. Test spiders spent more time in the vicinity of a source of human odour (previously worn socks) when the alternative was unworn socks...

Acute febrile hepato-renal dysfunction in the tropics: co-infection of malaria and leptospirosis [Journal of Infection and Chemotherapy, 16 February 2011] — (English)
We report two cases of malaria from India with compelling serologic evidence of coexistent acute leptospirosis...

Our impasse in developing a malaria vaccine [Cellular and Molecular Life Sciences DOI: 10.1007/s00018-011-0634-5] — (English)
A conclusion is that a vaccine must identify novel antigens or epitopes that are not normally immunogenic and which are therefore not under immune pressure and most likely to be conserved between different strains...

Cytochrome P450 6m2 From The Malaria Vector Anopheles Gambiae Metabolizes Pyrethroids: Sequential Metabolism Of Deltamethrin Revealed [Insect Biochemistry and Molecular Biology, doi:10.1016/j.ibmb.2011.02.003] — (English)
Our data indicates that CYP6M2 plays an important role in metabolic resistance to pyrethroids and thus an important target for the design of new tools to combat malaria...

Energy metabolism affects susceptibility of A. gambiae mosquitoes to Plasmodium infection [Insect Biochemistry and Molecular Biology doi:10.1016/j.ibmb.2011.02.001] — (English)
Our studies revealed that R females have reduced longevity, faster utilization of lipid reserves, impaired mitochondrial State-3 respiration, increased rate of mitochondrial electron leak and higher expression levels of several glycolytic enzyme genes...




Articles included in 'Malaria in the News' do not necessarily represent the opinion of the Roll Back Malaria Partnership or any of its individual partners.



Friday, February 18, 2011

This Is Rotary - Rotary International

Robert Semenuik: Personalizing the World Health Crisis


Personalizing the World Health Crisis

Fourteen million people die each year from treatable diseases like HIV/AIDS, malaria, tuberculosis, and diarrhea, while another two billion are infected. In addition to these main killers are the numerous little known diseases like sleeping sickness, river blindness, rotavirus, and trachoma, all of which shatter families, jolt economies and destabilize security and food supplies. More than one billion people lack access to clean water, and 2.6 billion lack access to sanitation. Yet the amount spent on world health is less than two percent of the global military budget. World health is a human right and the most pressing development issue facing us today.
By living among, and forming intimate friendships with the diseased and disenfranchised people whose stories are documented, this project aims to give a voice, hope and dignity to the victims, and humanize the crisis by putting faces and personalities on the overwhelming statistics.

HIV/AIDS

The first leg of this project documented disease and dislocation among the disenfranchisedSan of the Kalahari in Botswana. The Bushmen are the poorest of the poor in Botswana, which has one of the highest rates of HIV/AIDS in the world, with up to forty percent of adults infected. Dislocation and dispossession are major co-factors in the spread of AIDS, and many other diseases. People without homes get sicker than people with homes. And when people get sick they want to go home. Recently the court in Botswana ordered the government to allow Bushmen to return to their homes in the Central Kalahari Game Reserve, from where they have been forcibly removed, for many years, to what the Botswana government calls resettlements and that some Bushmen call "places of death." During the fall of 2005, I lived with Nanke, a single mother with AIDS, and her family who suffer TB, malaria, and alcoholism. He photographed everyday life.

TRACHOMA

There are an estimated 38 million blind people in the world - of those, 28 million are unnecessarily blind. The second leg of the project documented trachoma. Spread by flies, it is the world's leading cause of preventable blindness. Trachoma is pandemic in Ethiopia, where big strides are being made to eradicate this ancient disease of poverty and poor sanitation. As trachoma progresses, often for 15 years or more, the eyelids turn inward, scratching the eyeball causing unbearable itching, infection, and scarring that inevitably leads to blindness if not treated, early (with what amounts to a dollar's worth of antibiotics) or later with surgery.

MALARIA

The next leg of the project is about malaria. Malaria is pandemic in many places, especially in sub-Saharan Africa, but this story takes place where the fear originates: along the Thai/Burmese border, in Karen refugee camps, where the world's most resistant parasites and fatal strains of malaria thrive. No one knows why, even though the hospital and numerous malaria clinics in the Mae Sot district treat hundreds of thousands of patients every year, and researchers come from all over the world to study the problem. Malaria is the constant companion of everyone who lives here. Dr. Cynthia Maung has dedicated her clinic to the cause for over thirty years. But the war involves educating people, who change slowly, and may not even associate malaria with mosquitoes, and parasites that change too quickly for drugs to keep up. Mobile blood clinics make early falciparum diagnoses so that treatment can be rushed to the infected migrant population.
This project will illustrate the cultural politics and anthropology of malaria: how people experience it; how malaria shatters families, stunts and destabilizes economies, security and food supplies; how malariologists, technologists, educators, and a vast culture of malaria survivors fight what the WHO calls the "public health enemy number one."
Malaria cases, drug resistance, and mosquito persistence are worsening around the world. With the globe becoming more traveled and warmer, deforestation, expanding mosquito habitat, and indiscriminate anti-malarial use, the fear is that the world's most untreatable malaria will find its way to Africa and the temperate zones. Nevertheless, there are hopes for its eradication and this project will document the realities, dilemmas and consequences surrounding eradication programs, including DDT.
The story moves to Tanzania where the entire population is exposed to malaria for a least part of the year, and, where malaria is the country's biggest killer. Here communities are benefiting from new drugs and eradication strategies, including favoring the manufacture and distribution of insecticide impregnated bed nets, over indoor spraying of DDT. A dire shortage of the promising anti-malarial plant Sweet Wormwood has prompted a number of agencies to transplant the herb, which the WHO predicts will cut the world's malaria deaths in half, from China to Tanzania.
After malaria the project will focus on diabetes among Canada's First Nations people, tuberculosis in Russian prisons, obesity in America, river blindness, schistosomiasis or snail fever, lymphatic filariasis, and other diseases.

View Image Galleries:

  1. HIV/AIDS
  2. TRACHOMA
  3. MALARIA

Project-related links:

Work from Personalizing the World Health Crisis has been exhibited at universities and galleries and appeared in print media, including:
Selected Project links:
  • In Burma, Fever of War - a photo essay on The Tyee
  • SMRU: Shoklo Malaria Research Unit
  • Cover story: Robert Semeniuk's World Health project featured in the Seattle Times weekend magazine, "Terrible Truths: Photographer Robert Semeniuk won't let us look away," by Seattle Times writer Paula Bock, August 12, 2007.
  • Exhibition - Trachoma in Ethiopia, photographs from Personalizing the World Health Crisis, from The Gallery on Bowen Island and The Bowen Island Arts Council.
  • Trachoma in Ethiopia - a photo essay in Ascent Magazine
  • Uprooted After 30,000 Years - a photo essay on The Tyee
  • The San: Aids and Dislocation - a photo essay in Ascent Magazine
  • The San - photo feature in Cultural Survival Magazine, Spring 2006
  • Exhibition - The San: AIDS and Dislocation, Victoria School of Performing and Visual Arts Gallery, Edmonton -read the review see the show
  • Life and Death in the Kalahari - photo feature in The Toronto Star, August 14, 2005

For more information on how to support this project - 
please click here