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Malaria in the News
World Malaria Day 2011
21.03.2011
Announcements / Press Releases
Global Fund names former Health and Human Services Secretary Leavitt and former President of Botswana Mogae to lead an independent review of Global Fund financial safeguards [The Global Fund] — (English)
he Global Fund to Fight AIDS, Tuberculosis and Malaria today announced that former President of Botswana Festus Mogae and former U.S. Health and Human Services Secretary Michael O. Leavitt have agreed to lead a high-level panel of experts that will conduct an independent and thorough review of the Global Fund’s financial safeguards...
Anacor Pharmaceuticals and MMV sign agreement to pursue promising compound for malaria [MMV] — (English)
AN3661 will undergo preclinical studies with the hope of developing a new and effective next generation antimalarial...
UK to protect a quarter of Mozambique’s vulnerable population from malaria [DFID] — (English)
More than five million people - one million of them children under the age of five - will be protected from malaria in Mozambique with help from the British Government...
Global Malaria Programme director to arrive in Azerbaijan [Azerbaijan Business Center] — (English)
The UN office in Azerbaijan reports that the director of the WHO Global Programme on Malaria Robert Newman and regional adviser on Malaria of WHO Regional Office for Europe Mikhail Ezhov will come to Baku on 28-31 March of the year...
M&E of Malaria Programs Workshop [>MEASURE Evaluation] — (English)
MEASURE Evaluation, in partnership with the Centre de Recherche en Santé de Nouna (CRSN), the Centre de Recherche Internationale pour la Santé (CRIS) and the Unité de Formation et de Recherche en Sciences de la Santé (UFR/SDS) at the University of Ouagadougou...
RBM Writer [RBM] — (English)
Deadline for applications: 7 April 2011...
RBM Manager, Finance & Administration [RBM] — (English)
Deadline for applications: 24 March 2011...
RBM Resource Mobilization Officer [RBM] — (English)
Deadline for applications: 24 March 2011...
MMV is seeking to hire an Associate Director, Translational Medicine & Pharmaceutics [MMV] — (English)
Deadline for applications: 3 April 2011...
MMV is seeking to hire an Associate Director, Translational Medicine & Clinical Development, Project Leader [MMV] — (English)
Deadline for applications: 3 April 2011...
President's Malaria Initiative E-Newsletter [PMI] — (English)
March issue...
21.03.2011
Long-term plan drafted to rid nation of malaria [VietNamNet Bridge] — (English)
The Ministry of Health has drafted a national strategy to eradicate malaria over the next 20 years through early diagnoses, effective treatment and preventative measures......
New Technology Promises To Have A Major Impact On Supply Of Malaria Treatment Across The Developing World [MediLexicon] — (English)
Canada is delivering on its commitment to help the world's most vulnerable, thanks to new developments which will provide an affordable, reliable, and stable treatment for malaria that will save millions of lives, especially those of women and children in Africa......
Malaria-Erreger könnte durch Stören der Fortpflanzung bekämpft werden [DRadio] — (German)
Stört man die Fortpflanzung der Malaria-Erreger, könnte man künftig die Mensch-zu-Mensch-Übertragung der Krankheit verhindern......
Malariaprophylaxe bei chronischen Krankheiten [Ärzte Zeitung] — (German)
Bei der Malariaprophylaxe müssen vor allem Herz- und Leberpatienten aufpassen, was sie nehmen. So sollte Doxycyclin nicht bei Leberfunktionsstörungen eingesetzt werden, wie Dr. Andreas Leischker vom Krankenhaus Maria-Hilf in Krefeld betont......
Rwanda: Malaria Decreases By 70 Percent [New Times via allAfrica.com] — (English)
Rwanda is on track to enter the malaria pre-elimination phase......
Navy Medical Researchers Explore Preventative Malaria Vaccines [Armed with Science] — (English)
Protecting our fighting forces against infectious threats such as malaria is why Navy Medicine and our sister services continuously conduct medical research. We want to provide our forward-deployed forces with the best in force health protection......
20.03.2011
WHO seeks strengthening of malaria controls [The Post] — (English)
THERE is need to strengthen capacity in the region for planning, management and expanded quality service delivery to overcome challenges being faced to control malaria, according to Dr Georges Ki- Zerbo......
19.03.2011
Major breakthrough in Malaria fight [CTV] — (English)
A group of Saskatoon researchers has reached a major breakthrough in the fight against Malaria. Scientists with the National Research Council in Saskatoon have helped create genetically engineered yeast that will be used to make an effective anti-malaria drug artemisinin......
Artesunate: A New Drug for Severe Malaria Patients [TopNews New Zealand] — (English)
Now there is better cure available for treatment of severe malaria as Cochrane researchers have succeeded in finding more efficient and effective anti-malarial drug than quinine, which could prevent the loss of life due to severe malaria among patients......
Afrikas Kampf gegen Malaria [Deutsche Welle] — (German)
In Afrika sterben heute viel weniger Menschen an Malaria als noch vor zehn Jahren. Und neue Forschungen im Kampf gegen die Malaria übertragenden Stechmücken versprechen große Erfolge gegen das Sumpffieber......
18.03.2011
Malaria, still PNG's mass killer [Radio Australia News] — (English)
Up to 800 people are dying of malaria each year in Papua New Guinea......
"LifeLine", Hosted by Joan Lunden, is Producing a Series on Malaria [Einnews Portugal] — (English)
LifeLine hopes to raise awareness on a parasitic disease affecting much of the tropics and sub tropics - malaria......
Insight Into Parasite 'Family Planning' Could Help Target Malaria [Science Daily] — (English)
Fresh insight into the way the parasite that causes malaria reproduces could lead to new treatments to help curb the spread of the disease......
17.03.2011
Fresh insight into parasite's reproductive strategy can prevent malaria spread [News-Medical.net] — (English)
Fresh insight into the way the parasite that causes malaria reproduces could lead to new treatments to help curb the spread of the disease......
Malaria cases dip in Cordillera [Manila Bulletin] — (English)
Malaria remains to be endemic or prevalent in 25 of the 76 municipalities in the Cordillera but a significant decrease in the number of malaria cases has been noted with the continuing effort of the Department of Health (DoH), in partnership with the different local government units and private (health) organizations, to eradicate the deadly disease......
16.03.2011
Herbal Derivative Wins Praise as Malaria Treatment [U.S. News & World Report ] — (English)
Artesunate should replace quinine as the drug of choice for treating malaria, according to an updated review of clinical trial results......
Identification of two new protective pre-erythrocytic malaria vaccine antigen candidates [Malaria Journal 2011, 10:65] — (English)
The authors combine two antigens that are minimally effective for inducing sterile protection in rodents, and achieve a multicomponent vaccine that is modestly effective for inducing sterile protection in their model......
Effectiveness of artemether-lumefantrine provided by community health workers in under-five children with uncomplicated malaria in rural Tanzania: an open label prospective study [Malaria Journal 2011, 10:64] — (English)
Provision of artemether-lumefantrine by community health workers for unsupervised malaria treatment at home was highly effective, which provides an evidence base for scaling-up implementation of home-management of malaria using AL in Tanzania......
A phase I trial to evaluate the safety and pharmacokinetics of low-dose methotrexate as an anti-malarial drug in Kenyan adult healthy volunteers [Malaria Journal 2011, 10:63] — (English)
An interesting pharmacokinetics study of an old anti-cancer drug, which may be a potentially useful anti-malarial at lower doses......
Development of a new version of the Liverpool Malaria Model. II. Calibration and validation for West Africa [Malaria Journal 2011, 10:62] — (English)
The present study has calibrated an entomological and parasitological validated version of the LMM. For West Africa, the authors have compiled a rich archive of validation data from literature in terms of eleven entomological and parasitological variables. LMM simulations were rated by means of a novel problem-adapted validation procedure, which considers the limited availability of malaria field observations in the area of weather stations......
Ghana-Cuba sign $ 74m MOU to fight Malaria [GBC] — (English)
Ghana and Cuba have signed a $ 74m Memorandum of Understanding to reduce the incidence of malaria in the country by 80% in two years......
Neues Malaria-Präparat wirkt effektiv [Apotheken] — (German)
Wirkstoff Artesunat senkt Sterberate......
15.03.2011
Mitochondrial genes support a common origin of rodent malaria parasites and Plasmodium falciparum's relatives infecting great apes [BMC Evolutionary Biology 2011, 11:70doi:10.1186/1471-2148-11-70] — (English)
This study sheds light on the evolutionary history of Plasmodium falciparum, a major issue for human health......
Randomized controlled trials of malaria intervention trials in Africa, 1948 to 2007: a descriptive analysis [Malaria Journal 2011, 10:61] — (English)
A random sample of 92 confirmed RCTs (from a total of 943 reports obtained between 1948 and 2007) was prepared. Most trials investigated drug treatment in children with uncomplicated malaria. Few trials reported on treatment of severe malaria or on interventions in pregnant women......
PvRON2, a new Plasmodium vivax rhoptry neck antigen [Malaria Journal 2011, 10:60] — (English)
The identification and partial characterization of the first Plasmodium vivax rhoptry neck protein are described in the present study. This protein is homologous to Plasmodium falciparum RON2, previously been shown to be associated with PfAMA-1, suggesting a similar role for PvRON2......
Knockdown resistance (kdr)-like mutations in the voltage-gated sodium channel of a malaria vector Anopheles stephensi and PCR assays for their detection [Malaria Journal 2011, 10:59] — (English)
Two alternative kdr-like mutations, L1014S and L1014F, were detected in An. stephensi with a high allelic frequency of L1014S. The occurrence of L1014S is being reported for the first time in An. stephensi. Two specific PCR assays were developed for the detection of two kdr-like mutations in An. stephensi......
Exposure of the Plasmodium falciparum clonally variant STEVOR proteins on the merozoite surface [Malaria Journal 2011, 10:58] — (English)
These data suggest for a role for STEVOR in immune evasion by P. falciparum merozoites to allow successful invasion of erythrocytes. Additionally, the expression of STEVORs in the schizont stage may only represent a step in the biogenesis process of the merozoite surface coat......
Global deaths from AIDS, malaria declining [Times of India] — (English)
A new study has found that scientists working for healthier humans around the globe are making headway in fighting communicable diseases such as AIDS, malaria and diarrhea. The study came from the Frederick S. Pardee Center for International Futures in the University of Denver's (DU) Josef Korbel School of International Studies......
Articles requiring subscription
Malaria-attributed death rates in India: Correspondence by Ashwani Kumar, Virendra Kumar Dua, Pradipsinh K Rathod [The Lancet, Volume 377, Issue 9770, Pages 994 - 995, 19 March 2011 ] — (English)
For 1997 and 1998, we reviewed the Medical Certification of Cause of Death under the Civil Registration Scheme that covered 8000 hospitals across India...
Malaria-attributed death rates in India: Correspondence by Ashwani Kumar, Virendra Kumar Dua, Pradipsinh K Rathod [The Lancet, Volume 377, Issue 9770, Pages 994 - 995, 19 March 2011 ] — (English)
For 1997 and 1998, we reviewed the Medical Certification of Cause of Death under the Civil Registration Scheme that covered 8000 hospitals across India...
Malaria-attributed death rates in India: Correspondence by Neena Valecha, Sarah Staedke, Scott Filler, Arthur Mpimbaza, Brian Greenwood, Daniel Chandramohan [The Lancet, Volume 377, Issue 9770, Pages 994 - 995, 19 March 2011 ] — (English)
We believe that Dhingra and colleagues might have substantially overestimated the number of malaria deaths in India for the following reasons...
Malaria-attributed death rates in India: Correspondence by Buddha Basnyat [The Lancet, Volume 377, Issue 9770, Pages 994 - 995, 19 March 2011 ] — (English)
Neeraj Dhingra and colleagues report higher estimates of annual malaria deaths in India than previously suggested...
Malaria-attributed death rates in India: Correspondence by Andrew Deonarine [The Lancet, Volume 377, Issue 9770, Pages 994 - 995, 19 March 2011 ] — (English)
The methods used by Neeraj Dhingra and colleagues1 have some potential sources of inaccuracy and bias, which could alter the number of malaria-attributed deaths. Although Dhingra and colleagues were quite fastidious in their methods, concerns about the accuracy of diagnoses by physicians and the quality of the original narratives persist...
Malaria-attributed death rates in India: Correspondence by Vinod P Sharma, Prabhat Jha, Neeraj Dhingra, Raju M Jotkar, Richard Peto [The Lancet, Volume 377, Issue 9770, Pages 994 - 995, 19 March 2011 ] — (English)
Since infection with P falciparum can progress rapidly from mild symptoms to life-threatening disease, in some of the parts of India with limited health-care facilities, many cases are never diagnosed and malaria remains a major cause of death...
10-Minute Consultation Malaria [BMJ 2011; 342:d1149 doi: 10.1136/bmj.d1149] — (English)
A 30 year old pregnant woman going home on holiday to Nigeria attends the clinic to get a prescription for malaria prevention tablets for herself and her two children...
Structure of a Plasmodium falciparum PfEMP1 rosetting domain reveals a role for the N-terminal segment in heparin-mediated rosette inhibition [PNAS] — (English)
We present a structural and functional study of the N-terminal domain of PfEMP1 from the VarO variant comprising the N-terminal segment (NTS) and the first DBL domain (DBL1α1), which is directly implicated in rosetting. We demonstrate that NTS-DBL1α1-VarO binds to RBC and that heparin inhibits this interaction in a dose-dependent manner, thus mimicking heparin-mediated rosette disruption...
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria [PNAS March 15, 2011 vol. 108 no. 11 4400-4405] — (English)
Ozonide OZ439 is a synthetic peroxide antimalarial drug candidate designed to provide a single-dose oral cure in humans. OZ439 has successfully completed Phase I clinical trials, where it was shown to be safe at doses up to 1,600 mg and is currently undergoing Phase IIa trials in malaria patients...
Artesunate versus quinine for treating severe malaria [A reprint of a Cochrane review, prepared and maintained by The Cochrane Collaboration and published in The Cochrane Library 2010, Issue 1] — (English)
Intravenous artesunate is the drug of choice for adults with severe malaria, particularly if acquired in Asia. This review did not identify sufficient data to make firm conclusions about the treatment of children or the effectiveness of intramuscular artesunate. There is an urgent need to compare the effects of artesunate with quinine in African children with severe malaria. The applicability of these results to Asian children and the ethics of further research are points of debate....
Nitric Oxide Protection Against Murine Cerebral Malaria Is Associated With Improved Cerebral Microcirculatory Physiology [Journal of Infectious Diseases, Advance Access 10.1093/infdis/jir058] — (English)
NO protection against CM is associated with improved brain microcirculatory hemodynamics and decreased vascular pathology...
ogaraK: A population genetics simulator for malaria [Bioinformatics (2011) doi: 10.1093/bioinformatics/btr139] — (English)
Here we present ogaraK, a population genetics simulator for modelling the spread of drug resistant malaria...
Cutting Edge: Attrition of Plasmodium-Specific Memory CD8 T Cells Results in Decreased Protection That Is Rescued by Booster Immunization [The Journal of Immunology February 28, 2011 1003949] — (English)
We show that P. berghei circumsporozoite-specific memory CD8 T cells underwent significant attrition in numbers in mice subjected to unrelated infections...
Prevention and control of malaria and sleeping sickness in Africa: Where are we and where are we going? [Parasites & Vectors 2011, 4:37doi:10.1186/1756-3305-4-37] — (English)
The International Symposium on Malaria and Human African Trypanosomiasis: New Strategies for their Prevention & Control was held 7- 8 October, 2010 in Cotonou, Benin with about 250 participants from 20 countries...
X-Ray Microanalysis Investigation of the Changes in Na, K, and Hemoglobin Concentration in Plasmodium falciparum-Infected Red Blood Cells [Biophysical Journal, Volume 100, Issue 6, 1438-1445, doi:10.1016/j.bpj.2011.02.007] — (English)
The model predicted a critical contribution of excess hemoglobin consumption to cell integrity (the colloidosmotic hypothesis). Here we tested this prediction with the use of electron-probe x-ray microanalysis to measure the stage-related changes in Na, K, and Fe contents in single infected red cells and in uninfected controls...
Studies on the behaviour of peridomestic and endophagic M form Anopheles gambiae from a rice growing area of Ghana [Bulletin of Entomological Research, CDOI: 10.1017/S0007485311000125] — (English)
It is hypothesised that the ‘paddy paradox’ is due to young pre-gravid insects dispersing more widely than gravid ones, not necessarily to low survival in the mosquito...
A microfabricated deformability-based flow cytometer with application to malaria [Lab Chip, 2011, 11, 1065-1073 DOI: 10.1039/C0LC00472C] — (English)
This device is especially applicable to heterogeneous cell populations. We demonstrate its ability to mechanically characterize a small number of P. falciparum-infected (ring stage) RBCs in a large population of uninfected RBCs...
IL3 variant on chromosomal region 5q31–33 and protection from recurrent malaria attacks [Hum. Mol. Genet. (2011) 20 (6): 1173-1181. doi: 10.1093/hmg/ddq562 ] — (English)
Using segregation analyses, control of malaria parasites has previously been linked to a major gene within the chromosomal region 5q31–33, but also to complex genetic factors in which effects are under substantial age-dependent influence. However, the responsible gene variants have not yet been identified for this chromosomal region. In order to perform association analyses of 5q31–33 locus candidate single nucleotide polymorphisms (SNPs), 1015 children were recruited at the age of 3 months and followed monthly until the age of 2 years in an area holoendemic for Plasmodium falciparum malaria in Ghana...
Malaria-attributed death rates in India: Correspondence by NK Shah, AC Dhariwal, GS Sonal, A Gunasekar, C Dye, R Cibulskis [The Lancet, Volume 377, Issue 9770, Pages 994 - 995, 19 March 2011 ] — (English)
As a component of the Million Death Study, Neeraj Dhingra and colleagues (Nov 20, p 1768) estimate by verbal autopsy that about 200 000 people die of malaria in India each year. This estimate is much higher than the WHO estimate of between 10 000 and 21 000 deaths in 2006...
Articles included in 'Malaria in the News' do not necessarily represent the opinion of the Roll Back Malaria Partnership or any of its individual partners.
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