Sunday, October 3, 2010

Towards Malaria Eradication

Science 14 May 2010:
Vol. 328. no. 5980, pp. 862 - 866
DOI: 10.1126/science.1184785



REVIEW

That Was Then But This Is Now: Malaria Research in the Time of an Eradication Agenda

Stefan H. I. Kappe,1,2,* Ashley M. Vaughan,1 Justin A. Boddey,3 Alan F. Cowman3
The global research community must take up the challenge to work toward the eradication of malaria. In the past, malaria research has focused on drugs and vaccines that target the bloodstage of infection, and mainly on the most deadly species, Plasmodium falciparum, all of which is justified by the need to prevent and treat the disease. This work remains critically importanttoday. However, an increased research focus is now being placed on potential interventions that aim to kill the parasite stages transmitted to and by the mosquito vector because they may represent more vulnerable targets to stop the spread of malaria. Here, we highlight some of theresearch into malaria parasite biology that has the potential to provide new intervention targets for antimalarial drugs and vaccines.
1 Seattle Biomedical Research Institute, Seattle, WA 98109, USA.
2 Department of Global Health, University of Washington, Seattle, WA 98195, USA.
3 The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia.


Check out http://www.sciencemag.org/cgi/content/abstract/328/5980/862 for more.

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