Sunday, October 3, 2010

Trends In Parasitology


doi:10.1016/j.pt.2010.03.007 | How to Cite or Link Using DOI
Copyright © 2010 Elsevier Ltd All rights reserved.
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An update on the rapid advances in malaria parasite cell biology
Isabelle Coppensa, David J. Sullivana and Sean T. PriggeaE-mail The Corresponding Author
a Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA

Available online 9 April 2010. 

Recent years have seen rapid advances in our understanding of malaria parasite cell biology. Some of this progress has been the result of developments in genetic techniques, advances in imaging technology, and new molecular tools. We focus on three aspects of parasite cell biology: (i) plastid metabolism, (ii) sporozoite biology, and (iii) protein transport to and from the host erythrocyte. In each case recent work has led to a deeper understanding of parasite biology, often at the expense of previously accepted paradigms. These studies also highlight the impediments, technical and otherwise, that will have to be overcome for continued rapid progress in these fields.


Article Outline

Research advances in malaria
Apicoplast metabolism: drug target or vaccine target?
The parasite protein trade: import and export
Surprising twists in the journey of sporozoites in the mammalian host
Concluding remarks and future directions
Acknowledgements
References

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